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The no-wash assay allowed non-IgE antibodies to interact with the biotinylated allergens in competition with the solid-phase absorbed IgE antibodies (15). The numerical readout for the Centaur assay has previously been described (11, 15, 21). The assay readout is (IgE binding in competition with non-IgE)/(IgE binding with remaining Igs [http://www.selleckchem.com/products/XL184.html click here] washed away). The ratio will be close to 1, that is equivalent to pretreatment values where no blocking antibodies have been induced. Analysis of changes from pretreatment visit in log-transformed specific IgE, log-transformed specific IgG4, IgE-FAB and specific IgE-blocking factor was performed with a linear mixed-effects model. The model included as fixed effects the pretreatment value, treatment group, visit and treatment-group-by-visit interaction. To allow correlation of observations on the same patient, a random subject effect was included. A different error variance was specified for each treatment group. The relationship between combined symptom and medication scores during peak season and change in specific IgG4 from pretreatment visit to 1st maintenance injection visit was analysed. The 221 subjects were allocated into three group levels of about equal size based on the quantity of specific IgG4. In this way, an ordered categorical variable on three levels was created. Then, the combined symptom and medication score was analysed with a linear mixed-effects model, using the created categorical variable as fixed effect and the pollen region as [http://www.selleckchem.com/products/CP-690550.html Tofacitinib mw] a random effect. By including pollen region, possible differences in CSMS owing to differences in pollen exposure between different geographic regions in the UK are accounted for. Similar analyses were performed for the relationship [https://en.wikipedia.org/wiki/S1PR1 S1PR1] between combined symptom and medication score during peak season and change in IgE-FAB and specific IgE-blocking factor. For the subgroup of 162 grass-allergic participants who received Alutard P.?pratense extract 100?000 SQ-U or placebo, Friedman��s proportion of treatment effect explained by IgG4, IgE-FAB or specific IgE-blocking factor was estimated (22). Correlation coefficients were obtained using Spearman��s rank method. All hypothesis testing was exploratory. Two-sided P-values are presented. P-values