Просмотр исходного текста страницы A 10-Second Trick Intended for Roxadustat

Eleven [http://www.selleckchem.com/products/scr7.html SCR7 nmr] (28.9%) had distal gastro-oesophageal reflux, and 20 (52.6%) had both distal and proximal reflux out of the 38 symptomatic patients. In the asymptomatic group, six (50%) had distal reflux, and two (16.6%) had both distal and proximal reflux. The pattern of GORD in these patients is shown in Table?2. The relationship between the symptoms and the results of 24-h dual-probe oesophageal pH monitoring is shown in Table?3. In those patients who were symptomatic for GORD, 20 patients had proximal pH 1.1% of total time. In 12 asymptomatic patients, three had proximal oesophageal pH 1.1% of total time. The difference between these two groups was not significant with a P-value of 0.08. Thirty-one symptomatic and eight asymptomatic patients had distal oesophageal pH of [http://www.selleckchem.com/products/fg-4592.html check details] GORD may exacerbate symptoms of asthma. These mechanisms could be extrapolated to patients with COPD who suffer from abnormal thoracoabdominal functional anatomy resulting in higher gastric [https://en.wikipedia.org/wiki/PTPRJ PTPRJ] and lower intrathoracic pressures. There is also a very high prevalence of gastro-oesophageal reflux symptoms in patients with COPD.8,13,14 It also may lead to exacerbation in COPD as shown in many studies.15�C17 The prevalence of GORD in COPD patients has until now been evaluated in only a few studies,3�C7 all in patients with severe disease. In the present study, all the patients were of either mild or moderate stage COPD according to GOLD guidelines. To the best of our knowledge, Kempainen et?al.3 and D'Ovidio et?al.4 are the only previous investigators who used dual-probe 24-h oesophageal pH monitoring for diagnosing GORD in COPD. Kempainen and co-workers3 in their prospective randomized study have found that the total prevalence of GORD was 57% in advanced COPD patients. The study included 41 patients with advanced COPD with a mean forced expiratory volume in 1?s of 24% predicted. The prevalence of distal GORD, and both distal and proximal GORD was shown to be 12% and 32%, respectively. There were abnormal proximal pH measurements despite having normal distal probe results in 15% of the patients.