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15 VBT is defined as a confirmed increase in HBV DNA level of more than 1 log IU/mL compared to the [http://www.selleckchem.com/products/r428.html selleck chemicals] nadir HBV level achieved during therapy. Biochemical response is defined as a normalization of ALT (��40 IU/L). Diagnosis of liver cirrhosis was based on the histological findings or radiological findings together with clinical features indicative of portal hypertension, such as thrombocytopenia (platelet count [http://www.selleckchem.com/products/jq1.html JQ1] those, 18 patients were excluded for multidrug resistance, and 58 patients were excluded for follow-up duration [https://en.wikipedia.org/wiki/E-64 E-64] for medication change to TDF in NA-experienced patients were PVR (n=45), withdrawal hepatitis after discontinuation of prior NA therapy (n=13), virological breakthrough (n=10), emergence of antiviral resistance (n=2), myopathy (n=2) and pregnancy (n=2). Mean duration of washout period in patients with withdrawal hepatitis was 49.7 weeks. Prior history of NA treatment and types of antiviral resistance were summarized in Table 2. Baseline serum HBV DNA was significantly higher in NA-na?ve than NA-exp group (5.9��2.0 log IU/mL vs. 3.9��2. log IU/mL, P