Просмотр исходного текста страницы Few Time Saving Procedures For GNAT2

Table 3 Genetic score frequencies per quartile. Estimated effects NN is a classifier that yields multiple estimated effects (depending on the number of neurons), which complicates the interpretation of the results. For that reason, estimates shown in this section are results from the Logistic Regression model. Table ?Table44 shows the estimated Odds Ratio for the significant covariates in all models. If these covariates are not augmenting T2D risk, we would expect an OR estimate and both limits of the 95% confidence interval to include 1.0. All covariates except the Principal Components were significantly associated to diabetes [http://www.selleckchem.com/CDK.html selleck chemical] (P  describing one model (GENSBMI) suffices to understand the effect of the covariates in the prediction of diabetes. For GENSBMI, gender had [http://www.selleckchem.com/products/SNS-032.html SNS032] an OR = 0.60 which implies a much lower risk of developing T2D in women when compared to men. The Cohort's odds ratio (OR = 0.45), implies a lower risk of T2D in Offspring members in comparison to the Original Cohort. Exposure time had an OR of 1.03, resulting in a 3% increase in risk of development for every year of exposure. The OR for the Genetic Score is approximated to 1.1, which implies an increase in risk of developing T2D, with the increase in value of the genetic score. The OR for BMI was 1.13 in the models that included BMI. This value demonstrates there is a 13% increment in risk of T2D when increasing 1 kg/m2 in BMI. Table 4 Estimated odd ratios (95% C.I) for covariates in risk assessment models**. SNP estimated effects Table ?Table55 provides [http://en.wikipedia.org/wiki/GNAT2 GNAT2] the P-value of the 21 SNPs that gave a statistical association with T2D in our study; we also present the P-value of those SNPs, in association to BMI and WHR as reported in the Giant Consortium (Heid et al., 2010; Speliotes et al., 2010). Only four SNPs found in the genes GLIS3, PTPRD, TCF7L2, and TSPAN8; had an association with a P-value less than 0.001. The SNPs: rs11717195, rs17301514, rs4299828, rs11063069, and rs10842994 have a P-value less than 0.1, therefore suggested as possible risk genetic variants. A total of three SNPs, each pertaining to a different gene, were found to be associated to WHR. These genes were: GCKR (Glucokinase Regulatory Protein), IGF2BP2 (Insulin-Like Growth Factor 2 MRNA Binding Protein 2), and PTPRD (protein tyrosine phosphatase receptor D). In addition, two SNPs strongly associated to BMI, were located in the genes IRS1 (Insulin Receptor Substrate 1) and TCF7L2 (Transcription Factor 7-Like 2). Table 5 P-value for the evaluated SNPs and their reported P-values for association to WHR and BMI in the giant consortium. Interaction with BMI Our results suggest SNP by BMI interaction with five SNPs at a P