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Simplification of ligaments near spinal segments should be avoided in future studies, which should incorporate muscles and ligaments with mechanical properties and proper biomechanical characteristics accompanied by cadaveric experiments. CONCLUSION The results of the present model predict the effect of Coflex? on the reduction of stress and strain on the posterior annulus and facet joints of the treated level in cases of extension and compression. In addition, it is postulated that Coflex? can adversely concentrate the stress on the facet joints of the adjacent levels, the junction part of the spinous process, and the bending portion of the device. Thus, [http://www.selleckchem.com/products/BEZ235.html BEZ235 supplier] Coflex? may lead to fatigue fracture of either spinous process or the device. Acknowledgements This study was supported by a grant of the Korea Healthcare technology R&D project, Ministry for Health & Welfare Affairs, Republic of Korea (A111016) and by a grant from the Institute of Medical System Engineering (iMSE) in [http://www.selleckchem.com/products/blu9931.html buy BLU9931] the GIST, Korea.""Since percutaneous vertebroplasty as a treatment option for vertebral angioma was reported in 1987, minimally invasive management including vertebroplasty (VP) and kyphoplasty (KP) using bone cement has been a popular treatment option for osteoporotic compression fractures2,8,15,24). Several studies showed the comparable outcome of patients without VP to patients with VP, and many articles have presented the effectiveness of a VP on the clinical outcome1,3,7,12). However, some patients who exhibit osteoporotic compression fractures in the thoracic spine complained of back pain and pain of nonmidline [http://en.wikipedia.org/wiki/17-Dimethylaminoethylamino-17-demethoxygeldanamycin 17-DMAG (Alvespimycin) HCl] areas such as the rib, chest, hip, groin, and buttocks, simultaneously6,10,18,19). Among the non-midline pains, the ribs were the most common site and, the overall response of VP for the non-midline pain was 83%10). The purpose of this study was to evaluate the effect of vertebroplasty on costal pain and to identify factors related to costal pain for patients with osteoporotic thoracic compression fractures. MATERIALS AND METHODS 1. Patient Selection We retrospectively reviewed the charts and radiographs of patients who were treated with vertebral augmentation for vertebral compression fractures from January 2005 to January 2010. Thirty-five patients were selected according to the following inclusion criteria: (1) the patients were diagnosed with osteoporosis (T score