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TAKASHI IWANAGA, HIROAKI KUME, NAMI OKIMOTO, NANASE WATATANI, SHU IMBE, HIROYUKI MIYAJIMA, HIROSHI SANTO, AKIKO SANO, OSAMU NISHIYAMA, HIROYUKI SANO, YUJI HIGASHIMOTO, HIROKAZU NAKAJIMA, YUJI TOHDA Division of Respiratory Medicine and Allergology, Kinki University Faculty of Medicine, Osakasayama, Japan Background?In the daily care of asthma, the degree of airflow obstruction [http://www.selleckchem.com/products/Abiraterone.html Abiraterone purchase] as measured through spirometry is used as an index of asthma control, but because the implementation of spirometry requires the maximal forced expiration of the subject, this examination is a burden for elderly subjects. Impulse oscillation system (IOS) is able to measure airway resistance and reactance under quiet breathing using impulse waves. However, the usefulness of evaluating IOS parameters in elderly asthmatics is not clear. We investigated the usefulness of IOS and the correlation between IOS and spirometry in elderly patients with asthma. Method?IOS, spirometry [http://www.selleckchem.com/products/ly2835219.html LY2835219 mouse] and flow volume curve were performed for 51 elderly (65 years old or older: elderly group) and 58 non-elderly (below 65 years old: non-elderly group) patients with asthma. Results?There were significant correlation between IOS parameters (R5, R5-R20, Fres, X5) and lung function (%FEV1, %Vdot50, %Vdot25, %MMF) in each group. R5, R5-R20, X5 and Fres were significantly correlated with age, with Fres showing the strongest association. R5 (0.30 vs. 0.40, P? the non-elderly group. X5 showed significantly low value in the elderly group than in the non-elderly group (?0.11 [http://en.wikipedia.org/wiki/Vatalanib Vatalanib (PTK787) 2HCl] vs. ?0.15, P?