Просмотр исходного текста страницы Rumours, Manipulating Combined With XAV-939

1.2600. Adverse events were evaluated descriptively. Immunogenicity results shown here were analyzed at SSI and LUMC using Prism 6.04 for Windows (GraphPad Software, Inc., La Jolla, CA 92037, USA). Change from baseline to each observed visit within groups and comparisons between groups were compared using Kruskal�CWallis test with Dunn's correction. No formal sample size calculation was performed in this trial. An alpha [http://www.selleckchem.com/products/XAV-939.html XAV-939 datasheet] adjuvant), 10 subjects (2 male, 8 female) with 50?��g H1?+?125/25?��g CAF01 (low adjuvant group), 11 subjects (2 male, 9 female) with 50?��g H1?+?313/63?��g CAF01 (intermediate adjuvant group) and finally, 10 subjects (1 male, 9 female) with 50?��g H1?+?625/125?��g CAF01 (high adjuvant group). A total of 34 subjects were included in the per-protocol population and 7, 9, 10 and 8 from groups 1, 2, 3 and 4, respectively, were included in the immunogenicity analysis (Fig. 1). Long-term visits, 150 weeks after initial enrolment, were successfully conducted for 31 out of the original 34 per protocol trial subjects; 7, 9, 9 and 6 from groups 1�C4, respectively. All 38 subjects with at least one vaccination were included in the safety analysis. No vaccine related serious or severe [http://www.selleckchem.com/HDAC.html selleck chemicals llc] adverse reactions occurred during the trial. Loco-regional injection site reactions occurred more frequently in those given the CAF01-adjuvanted antigen, and mainly included stiffness (defined as injection site movement impairment) and pain at the injection site one day after the vaccinations (Table 1). Of note, these reactions were not more frequent after the second vaccination and [http://en.wikipedia.org/wiki/3-mercaptopyruvate_sulfurtransferase 3-mercaptopyruvate sulfurtransferase] there was no significant difference between the three adjuvant doses. In total, any local adverse reactions were distributed with 6 events in 2 (29%) subjects in the non-adjuvanted group 1, 26 events in 10 (100%) subjects in group 2, 24 events in 9 (82%) subjects in group 3 and 26 events in 9 (90%) subjects in group 4. None of the subjects required analgesics and all experienced full recovery within a maximum of 4 days. A small, cold nodule at the injection site was noted in 1 subject in the intermediate CAF01 dose group 3. No signs of attendant inflammation or local vesiculation, axillary lymphadenitis or fistula did occur, and the nodule had disappeared within one week. One subject in group 4 (in concomitant treatment with tramadol) did not receive the second vaccination due to rash and itch on knees, hips and elbows, as a relation to the trial vaccine could not be ruled out.