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4%, the second stage in 39.8% and the third stage in 2.7% cases. Early CKD was detected in 52.0% respondents. In relation to the basic disease, early CKD was detected in 47.2% of hypertensive patients and in 54.0% of diabetic patients. Significantly the highest prevalence of early CKD was verified in the group of patients suffering from hypertension and DM type 2 combined (59.6%, p [http://en.wikipedia.org/wiki/Isotretinoin Isotretinoin] was found between eGFR and presence of albuminuria (r = -0.704, p [http://www.selleckchem.com/products/gdc-0068.html GDC-0068 nmr] HTN (r = -0.223, p = 0.003), stages of HTN (r = -0.190, p = 0.012), duration of DM type 2 (r = -0.241, p = 0.021), female gender (r = -0.432, p [http://www.selleckchem.com/products/incb28060.html this website] cause of ESRD is DM, but the second most common cause is glomerulonephritis in Japan and hypertension in the US (15). According to Renal Registry for Bosnia and Herzegovina, the number of dialysis patients in Bosnia and Herzegovina is constantly increasing. From 2002 to 2012, this number increased to 66.2% (1.531 vs. 2.544 ESRD patients). The most common cause of CKD in Bosnia and Herzegovina is glomerulonephritis. Diabetic disease is in third place and essential hypertension in fifth place. Hypertension is also a common comorbidity in patients with CKD. Diabetes mellitus was present in 18.2% of all ESRD patients in our country in 2012 (16). Johnson and colleagues report that early identification of patients with CKD and its treatment can reduce to 50% cardiovascular events and halt the progression of the disease to the terminal stage (14). Therefore, the detection of early CKD, especially in high-risk patients is of great importance, and primary care physicians play a crucial role in that program.