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1. The regression model showed a positive association between scores and education level (education coefficient �� = 0.27, p = 0.04). Those with Staurosporine raw MoCA score if his/her education was ��12 years. As this is the established adjustment method, we used it here for purposes of comparison �C see Nasreddine et al. [1]. Adjustments 2 and 3 were based on the education correction proposed by Chertkow et al. [2]. We, however, proposed two modifications. Adjustment 2: in addition to adding 1 point to the MoCA raw scores for those with 10-12 and 2 points for those with 4-9 years of education as proposed by Chertkow et al. [2], we also added 2 points for Resminostat those with mTOR inhibitor for each of them, we computed the SD of the diagnosis-adjusted residuals and the regression coefficient of education. Using 1,000 bootstrap samples, we generated distribution statistics for these two variables. The mean and the SD of these variables are summarized in table ?table3.3. While the SD of the residuals was reduced by all four adjustments, the most improved statistics were seen with adjustment 4. SD residuals and �� coefficients declined from 4.89 to 4.62 and from 0.27 to 0.07, respectively, between adjustment 1 and adjustment 4. These results showed that aggressive adjustment for those with the lowest education is the best strategy. Table 3 Comparisons of alternative MoCA score adjustments Sensitivity and Specificity of the MoCA Because our sample had only 6 normal participants, we were unable to evaluate the sensitivity and specificity of the MoCA test for detecting MCI. Instead, we examined the MoCA's sensitivity and specificity for predicting the diagnosis of dementia.