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001 and P>0.05, respectively, t-test; Fig. 2; miR-16 was used as a reference). The expression level of miR-1290 was significantly elevated in the serum of subjects with cervical cancer compared with that of CIN subjects (PLuminespib manufacturer lowest in healthy subjects, higher in CIN subjects, and the highest in cervical cancer patients. The median serum miRNA-1290 expression level was 0.78 in healthy subjects, 2.46 in CIN subjects and 4.04 in cervical cancer patients (PFleroxacin Figure 2. Circulating miR-1290 expression level in subjects with cervical cancer and cervical intraepithelial neoplasia (CIN) by quantitative polymerase chain reaction. The ROC curve indicated that the serum levels of miR-1290 may differentiate subjects with cervical cancer from healthy controls, with ROC curve areas of 0.7957 (95% confidence interval: 0.6937�C0.8977) (Fig. 3). With the cut-off at 3.959 (relative expression value), miR-1290 had a 90.3% sensitivity for cervical cancer and a specificity of 62.2%, compared with healthy controls. Figure 3. Area under the receiver operating characteristic curve for miR-1290 based on the quantitative polymerase chain reaction data. The cut-off level of plasma miR-1290 was 3.959; the sensitivity was 90.3% and the specificity was 62.2%. Serum miR-1290 in subjects at each stage of cervical cancer The median expression level of serum miR-1290 increased along with the stage of cervical cancer. The level in each group was as follows: Healthy group, 0.78; CIN1-2 group, 1.81; CIN3 group, 2.74; cervical cancer stage I group, 4.00; stage II group, 5.66; and stage III�CIV RO4929097 ic50 group, 5.59 (P