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Glycosylation has been indicated to be an important factor at early stages of cancer development (5). The present study demonstrated that 12 of the 14 early-stage gastric cancer patients (85.7%) were TAP-positive, supporting this role of TAP in the early stage of gastric cancer. Furthermore, the present study indicated the aptness of TAP detection for early diagnosis of gastric cancer and may be applied for screening of high-risk populations in combination with other diagnostic tools. He et al (17) revealed that TAP may be used as an indicator for the diagnosis of lung cancer and for evaluating the progress of lung cancer patients. Serum tumor markers are characteristic substances present in malignant cells or produced by abnormal malignant cells. Several of the Selleck RO4929097 most frequently used tumor markers, including carbohydrate antigen (CA)724, CA199, carcinoembryonic antigen (CEA) and CA242, have been confirmed to jointly provide information aiding in the diagnosis, classification, prognosis and treatment selection in gastric cancer (18�C21), while the value of information provided by of any of them alone is low. Jing et al (22) found that the sensitivity of CA724, CA199, CEA and CA242 was only 25.4, 36.2, 26.8 and 42.9%, respectively. Therefore, it is desirable to identify novel biomarkers with high sensitivity and specificity. The TAP testing kit manufactured by Zhejiang Fleroxacin Ruisheng Medical Technology, Ltd. contains a combination of lectins, which can recognize and bind to specific sugar molecules with high specificity, thus interlinking a variety of abnormal glycoproteins via their sugar chains to form characteristically shaped crystalloid, which can then be observed using the TAP detection image analyzer. The TAP detection system allows for combined detection of several tumor markers in the same system, therefore improving the sensitivity and specificity Luminespib of detection. The overall sensitivity and specificity of TAP detection in various types of cancer patients are 85.8 and 80.2%, respectively (23). Jin et al (24) reported that the sensitivity and specificity of TAP detection were 87.8 and 87.2%, respectively, for patients with malignant tumors of the digestive system. In the present study, 64.3% of gastric cancer patients were determined to be TAP-positive, which was significantly higher than the percentage of TAP-positive healthy volunteers (16.1%; P