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The ideal measure of Nepalese fruit and vegetable consumption warrants further discussion. This study found that sedentary lifestyle was an issue in this study population. The proportion RO4929097 of participants (21.6%) having insufficient physical activity (Fleroxacin in hypertensive participants than in normotensive participants. These findings were in line with results from previous studies conducted in Nepal [26, 28]. Like physical inactivity, obesity has also well-recognized independent relationship with a spectrum of cardiometabolic disorders including hypertension [49]. There are several mechanisms hypothesized to explain the link between obesity with hypertension [10, 11, 49, 50]. It is generally thought that the accumulation of visceral and ectopic fat in a number of tissues and organs alters the metabolic and hemodynamic Luminespib pathways, leading to the development of hypertension in obese people [49, 50]. The reduction of overweight and obesity by improving nutrition and increasing regular physical activity is the best way to avoid or improve hypertension [51]. Diabetes was associated with twofold increased odds of being hypertensive. The finding was consistent with the results of the studies conducted in similar settings of Kathmandu, Nepal [52, 53], and internationally [54, 55]. Hypertension is often reported to be one of the most common comorbid conditions in those suffering from diabetes. For instance, around half of diabetic patients in Australia have hypertension [56]. Similarly, almost a quarter of hypertensive patients were found to have diabetes in China and India [57, 58].