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Feasibility was tested through a questionnaire on comprehensibility, easiness of use, and completeness. Retest Megestrol Acetate reliability was assessed by testing consistency, in relation to pollen exposure, and for values recorded during each of 2 consecutive weeks. Results:? Convergent reliability analysis indicated a highly significant correlation between ACS? and global allergy severity (P?UMI-77 research buy Study participants evaluated the feasibility of the SMS as excellent. Conclusions:? Allergy-Control-SCORE? is a valid and reliable instrument to assess allergy severity in clinical trials and observational studies of respiratory allergic diseases. New treatments for allergic rhino-conjunctivitis and asthma are frequently proposed and tested for safety and clinical efficacy (1�C4). The need for well-performed clinical trials for respiratory allergies is therefore growing (5). The use of meta-analyses investigating the role of SIT and drugs for treating respiratory allergies has increased in the last decade (6�C10). Unfortunately, study heterogeneity greatly restricts the assembly of data from different trials and impairs the reliability of the outcomes of meta-analyses (6). This heterogeneity is attributable in part to the great variety of scoring systems used to measure disease severity (6). Indeed, there is still no universally accepted system to measure symptoms. Many scales have been created, based on the impact of disease on the daily life (quality of life, symptom-free days, medication-free days, visual-analog scales, etc.) (1, 6). The most frequently used approaches are symptom scores (SS), medication scores (MS), and combined symptom�Cmedication scores (SMS) (1). Nintedanib nmr Symptom and medication scores are recommended to measure the primary outcome of clinical trials on respiratory allergies (11), and their use is proposed by international regulatory agencies, such as the European Medicines Agency (EMA) (12). Unfortunately, no SMS has been validated so far and there is still no global consensus as to which SMS should be adopted. In an attempt to fill this gap, we elaborated an SMS defined Allergy-Control-SCORE? (ACS), developed this score over years, used it successfully in different clinical trials (13�C15), and designed a study to acquire information on the validity of this optimized Score. Allergy-Control-SCORE? covers drugs used in clinical trials and observational studies. This novel tool has now been validated by assessing reproducibility, discrimination capacity, and feasibility in healthy controls and patients with respiratory allergies.