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Table 4 Mean scores (��SD) and range of scores of the total THI scale and subscales of the Persian translation (THI-P) and the original version (THI-US). Table 5 Pearson product-moment correlations among THI-total and subscales of the Persian (THI-P) http://www.selleckchem.com/products/pci-32765.html and the original (THI-US) version Confirmatory Factor Analysis A confirmatory factor analysis was conducted to test whether the data could confirm the latent variables represented by the functional, emotional, and catastrophic subscales of the original version of the THI. The data were analyzed using a principal components factor analysis with varimax rotation. Because the KMO sampling adequacy was 0.930, the items were considered acceptable for factor analysis. The eigenvalues for these factors were 12.88 (Factor 1), 2.04 (Factor 2), and 1.08 (Factor 3). Factor 1 explained 51.52% of the variance, Factor 2 explained 8.16% of the variance, and Factor 3 explained 4.34% of the variance. To ensure distinct subscales, the differences between the highest and second-highest factor loadings had to exceed 0.20 to be retained in the analysis. In the three-factor solution, 10 items were loaded on more than one factor, with the remaining three factors consisting of 5, MK 2206 5 and 5 items, respectively. The results are given in Table 6. Table 6 Results of the three-factor solution of the 25 items of the Persian translation (THI-P) of the Tinnitus Handicap Inventory (THI)* Split Sample Validity We validated our analysis by conducting an analysis on each half of the sample. We compared the results of these two split-sample analyses with the analysis of the full data set. All of the communalities in both validation samples met the criteria. The pattern of loadings for both validation samples was the same, and the same as the pattern for the analysis using the full sample. This validation analysis supports a finding that the results of this principal component analysis were generalizable to the population represented by this dataset. Construct Validity Table 2 summarizes the correlations among scores on the THI-P for tinnitus severity and psychological distress. The mean VAS for tinnitus severity was 6.33 (SD=2.04). In 62 cases (59.8%) VAS was more than 5. A significant correlation was observed between TRIB1 THI-P and tinnitus severity according to the VAS (��=0.479, P= 0.001). The score for the BDI ranged from 0 to 39 (mean=4.7). In 19 cases (18.6%), depressive symptoms were reported. The STAI measures both anxiety as a general trait and the here-and-now level of perceived anxiety. The mean scores for two questionnaires were 41.1 and 44.5, respectively. In 41 (40.2%) and 56 cases (54.9%), state and trait anxiety, respectively, were pathologic. We found a high correlation between the BDI and STAI scores and tinnitus handicap scores of participants with tinnitus (�� = 0.66 and �� = 0.69�C0.77, respectively).