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Multiple endocrine and embryological parameters were also measured. We summarized the normally distributed continuous variables with mean and standard deviation; continuous variables with skewed distributions were summarized with median and interquartile range. Categorical variables were described with numbers and percentages. Univariable comparisons were made with student's t-test or Wilcoxon rank-sum test for continuous variables and Chi-squared test or Fisher's exact test for binary variables. Multivariable logistic regressions were performed to identify prognostic factors in each of the two treatment groups, which were restricted to the cycles with fresh embryo transfers. Continuous and binary predictor variables reported in previous studies were used for Aldosterone a preliminary model selection[7,8] [Table 1]. First, model-wise deletion (also known as complete case analysis) was used for model selection, during which cycles with missing data on any of the relevant variables was automatically dropped. Forward and backward stepwise model selections were conducted separately for each GnRHa group. Hosmer-Lemeshow goodness-of-fit test C59 in vivo and C-statistics were used to examine model accuracy. A variance inflation factor (VIF) were calculated, where VIF >10 were used to as an indicator of collinearity. Table 1 Candidate variables included the stepwise logistic regression model selection Missing data were then imputed using multiple imputations (MI) with chained equations.[9,10] Covariates retained in the selected regression models were all imputed using predictive mean matching for continuous variables and logistic functions for binary variables. The results of regressions with and without MI were compared. All the data analyses were performed with Stata Statistical Software (Release 13.1, by StataCorp LP, College Station, Texas, USA) and statistical significance was defined by two-sided P MLN8237 in vitro GnRHa protocols for down-regulation were identified. After the exclusion criteria had been applied, 3405 cycles remained in the analysis, among which 2106 used depot protocol and 1299 used daily low-dose protocols. Clinical pregnancy was examined in 2271 cycles with embryo transfers. The depot group were observably younger, had shorter duration of infertility, higher proportion of primary infertility and higher basal antral follicular count, which was echoed by the difference in endocrine and embryological outcomes [Tables ?[Tables22�C4]. In total, 64.1% of the patients in the depot group underwent fresh embryo transfers, 57.5% of whom achieved clinical pregnancies. In contrast, among the daily low-dose group, 71.0% of the patients underwent fresh embryo transfers, and 46.