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ESC, Lycopersicon esculentum Mill. var. esculentum; CER, Lycopersicon esculentum Mill. var. cerasiforme Table 1 IC50 values for the acetylcholinesterase and butyrylcholinesterase inhibitory activities, inhibition of FeSO4 and Quinolinic acid induced MDA production in rats brain homogenates in vitro. Total phenol and total flavonoid content and main carotenoid constituents ... The results of the Resiquimod total phenol and flavonoid contents of the samples are presented in Table ?Table1.1. The total phenolic content reported as gallic acid equivalent revealed that there was no significant (P>0.05) difference in the total phenolic content of the two tomato cvarieties [ESC (3.48 mg/g), CER (3.42 mg/g)], while the total flavonoid result revealed that ESC (0.62 mg/g) had significantly (PPI3K inhibitor to certain forms of Alzheimer��s disease and the neurotoxicity of certain plaques can be increased by the presence of BChE (17, 18). The ChE inhibition by the samples could be linked to their phenolic content as some phenolic compounds have been shown to inhibit AChE activity (19). The incubation of rat��s brain homogenates in presence of Fe2+ and quinolinic acid caused a significant increase (PCompound Library cost Elevated brain iron levels have been linked to the etiology of neurodegenerative conditions (20) as there is increased iron transport across the blood-brain barrier in conditions of extracellular iron overload (21). The increased iron in the brain results in the formation of reactive oxygen species which facilitates lipid peroxidation via Fenton reaction (22). This explains the significant increase in MDA content after incubation of rat��s brain homogenates in the presence of Fe2+ since there is a huge amount of brain phospholipids which contain oxidizable polyunsaturated fatty acids (PUFAs) which are easily attacked by radicals which could ultimately result in AD (23). The increase in MDA content after incubation of rat��s brain homogenates in presence of quinolinic acid can be attributed to the ability of quinolinic acid to form complexes that induce reactive oxygen species (ROS) formation and consequently MDA production via lipid peroxidation (24).