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Tukey's contrast test revealed significant between-group differences (p selleck chemicals 5). Figure 5 Environmental functioning in groups differing in severity of psoriatic skin changes (PASI) No significant relations (p > 0.05) were found between WHOQOL-BREF scores and the number of drugs used. This pattern holds for all four WHOQOL-BREF domains (correlation coefficients were low and non-significant: somatic (r = �C0.02), psychological (r = 0.04), social (r = �C0.07) and environmental (r = �C0.18)). A significant relation was found between duration of the last recurrence and the social dimension of quality of life (r = 0.28; p �� 0.05). Duration of the last remission was not related to quality of life: somatic (r = 0.05), psychological (r = 0.15), social (r = 0.17) and environmental (r = 0.01). Discussion When someone has a chronic disease he/she finds him/herself in a specific situation, not only clinically but also psycho-socially. This may affect quality of life. Assessment of health-related quality of life is a very Sitaxentan important supplementation of other methods of evaluation of disease severity and consequences for various dimensions of functioning. Quality of life monitoring may considerably help to objectivise treatment progress. Patients with a dermatological condition are particularly prone to misperception of their body, and especially their skin [6, 8]. Current research reports suggest that skin diseases may have a significant effect on functioning in all areas of life (e.g. professional, social and sexual) and on perceived quality of life [8, 18]. Our own research has confirmed these observations. We found that psoriatic skin changes significantly affect subjective quality of health and general quality of life. We also found that severity of psoriatic skin changes affects general quality of life (Figure 1). Patients with severe psoriatic changes were much less satisfied with life whereas patients with mild psoriatic changes (PASI CAL-101 nmr by the European Federation of Psoriasis Associations (EUROPSO) on the basis of research conducted in Europe: 60% of patients felt their disease to be a significant problem in their everyday functioning and reduced their satisfaction with life [5, 19]. Moons et al. [20] think that the level of satisfaction with life is the best indicator of general quality of life because it is a subjective evaluation of one's life. Patients know what aspects of life are most important for them and how affected they are by the disease. The results of the present study show that duration of recurrence correlates negatively with subjective quality of life: the longer the recurrence of psoriatic changes, the poorer the ratings of quality of life. No such correlation was found for the number of drugs used or duration of remission. These findings are consistent with findings reported by other researchers who found differences in quality of life depending on sex [11, 21, 22].