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The HIV-positive patients with AKI were divided using the ��RIFLE�� classification into three groups; Risk 4 patients (8%), Injury 10 patients (20%) and Failure 36 patients (72%). The HIV-negative group was also divided into three groups; Risk 26 patients (29%), Injury 24 patients (27%) and Failure 40 patients (44%). Table?2. Comparison between HIV-positive and HIV-negative patients presenting with selleck inhibitor acute kidney injury HIV-positive patients with AKI presented with more severe renal failure than HIV-negative patients. Using the RIFLE classification, 72% of HIV-positive patients presented in the most severe clinical category (Failure) when compared with 44% of HIV-negative patients (P = 0.014). Conversely, 29% of HIV-negative patients presented in the least severe clinical category (Risk) when compared with only 8% of HIV-positive patients (P = 0.038). Demographics There were 28 Epacadostat mw males (56%), with a mean age of 37.4 �� 10.4 years (range 21�C67 years) in the HIV-positive group with AKI, compared with 55 males (61%) with a mean age of 45.2 �� 17 years (range 18�C84 years) in the HIV-negative group. The majority of the HIV-positive patients were black (49 patients; 98%) and this was statistically significant when compared with the HIV-negative group (67 patients; 74%; P group, compared with 13 with diabetes ATPase mellitus (P = 0.014) and 19 with hypertension (P = 0.004) in the HIV-negative group. TB was diagnosed in 13 patients in the HIV-positive group, when compared with 2 in the HIV-negative group (P