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689; P Fossariinae postoperative sperm concentrations. No other variable demonstrated significant correlation. Conclusion: Baseline T was significantly low in men with varicocele compared with normal men. Varicocelectomy yielded significant T improvements among hypogonadal men but insignificant changes in eugonadals. Testosterone level changes after varicocelectomy significantly correlated inversely with baseline serum testosterone, and positively with sperm concentrations. Improved serum testosterone may have a role in predicting improvement of sperm concentration after varicocele repair. Should low testosterone be considered as a standalone indication for varicocelectomy remains to be determined. Urol Ann. 2015 Apr; 7(Suppl 1): S24�CS37. ? Clomiphene citrate and human chorionic gonadotrophin are good alternative therapy to testesterone in hypogonadal men seeking fertility 2015 Apr; 7(Suppl 1): S24�CS37. Clomiphene citrate and human chorionic gonadotrophin are good alternative therapy to testesterone in hypogonadal PI3K Inhibitor Library men seeking fertility Copyright and License information ? Copyright notice Mohammed Habous Elaj Medical Centers, United Arab Emirates Background and Objectives: Secondary, or late onset, hypogonadism (LOH) is a common problem in the ageing male population. It is significantly associated with various comorbidities such as obesity, diabetes, hypertension, and osteoporosis. Sunitinib concentration The standard therapy for hypogonadism is testesterone (T) which is not suitable for men seeking fertility �C a major problem in many men from the Gulf States. We wished to compare the efficacy of single agent clomiphene citrate (CC), human chorionic gonadtrophin (HCG), and a combination of the two in symptomatic patients of LOH wishing to preserve fertility. Methods: In this unblinded multicentre RCT, a total of 287 hypogonadal patients were randomly enrolled 2:2:1 into three groups. Group A (n = 88) were given HCG 5000 international units (i.u) intramuscularly once a week; group Group B (n = 82) took CC 50 mg daily, and group C (n = 41) took both HCG and CC (our previous standard treatment) A non-randomised control group of consecutive patients (D: n = 76) who did not wish to preserve fertility were commenced on Testosterone depot (Nebido). All patients had physical examination, T measurements and glycosylated haemoglobin (HbA1c) at baseline,1 month and 3 months, as were Quantitative ADAM questionnaire (qADAM) scores. LH and FSH levels were checked at baseline, after 1-month and 3 months. Results: The average age of patients were 42 being 47 for TU group, 40 for HCG, 38 for CC and 41 for combination group. All three treatments increased serum testosterone levels as shown in Table 1.