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Therefore, understanding the items and grading the severity were much easier than in the pilot study in which the patients were not provided visual explanations to help them filling out the study form. This study also confirms that PO-SCORAD is easy to understand and feasible for everybody, even for children who answered the questionnaire themselves. Indeed, no significant difference was observed in learn more the correlations between SCORAD and PO-SCORAD according to the age classes. Compared to other tools available for the self-assessment of AD severity, PO-SCORAD is the only one to measure the severity of AD both subjectively and objectively in a standardised way, with the help of an illustrated tutorial allowing the patient to accurately compare his/her symptoms with standardised photographs. The POEM scale is the only one that is adequately validated (17), but it does not allow comparison between patient��s and physician��s scores. Indeed, it is only based on subjective outcome measurements, which might introduce biases when they are used for rating quality of life impairment or the influence of comorbidity. The SA-EASI scale is fairly well correlated with the EASI scale (22), its counterpart for physicians, but it may be difficult for some patients with mild AD to distinguish between acute and chronic lesions (14). This has been confirmed in a recent study evaluating the relation of SA-EASI with the objective buy Nutlin-3a SCORAD in 60 children with moderate to severe eczema (23). Although the total SA-EASI and the SCORAD were well correlated (r?=?0.61, P?Oxymatrine found between the severity scores of SA-EASI and SCORAD scales (r?=?0.37, P?=?0.003), indicating that with the SA-EASI, the parents have difficulty in assessing the severity of their child��s AD. Like in our study, the authors highlight the value of AD grade illustrations and educative leaflets for training parents in grading AD severity and thus enhancing the correlation between the self-assessment score and the physician score. By contrast, a study evaluating the ADQ (16), another parent-administered scoring tool, showed a marked decrease in the correlation between ADQ and SCORAD after one week of an interventional programme (including therapeutic treatment and education) compared to inclusion (r?=?0.39 vs r?=?0.64), suggesting that ADQ is a poor assessment tool responding in a different manner to changes in skin condition with time. The Skin Detective scale, which includes items matching SCORAD, was designed, like PO-SCORAD, to allow a correlation between the perception of skin condition by the patient and the physician, respectively (15). However, the scale was difficult to understand by children under the age of 10, in particular for recording the extent of the disease on their body.