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Supplementary Table 3 Brain regions showing reduced gray matter volumes in subjects carrying risk alleles of Val allele of COMT and short allele of 5HTT (n=40) and those subjects having 1 or no risk allele of the COMT and 5HTT polymorphisms (n=26) X coor Y coor Z coor Brain region Z score 11.11 39.36 44.68 Right superior frontal gyrus* 4.099232 8.37 32.78 39.95 Right medial frontal gyrus* 3.610037 43.61 ?49.82 ?25.38 Right anterior selleck chemicals llc culmen 3.503955 8.53 ?85.27 ?7.71 Right lingual gyrus 3.487104 ?43.99 ?60.06 ?18.37 Left posterior declive 3.477983 15.59 ?80.33 ?15.23 Right posterior declive 3.409085 46.93 ?46.46 41.21 Right inferior parietal lobule 3.365151 6.27 40.55 ?10.69 Right anterior cingulate 3.278009 View it in a separate window Uncorrected significance threshold of pINCB28060 in vivo a significance threshold of pIsotretinoin of India (Grant No. BT/PR/8363/MED/14/1252 to J.P.J.). The authors would like to acknowledge Dr Bhavani Shankara Bagepally, Dr Nagaraj Moily, Ms Ammu Lukose, and Dr Vikram Arunachalam, research Fellows at MBIAL and Molecular Genetics Laboratory at NIMHANS for their kind assistance in subject recruitment and data compilation.""Prediction of antidepressant response has been an elusive goal.1) Several studies have investigated the relationship between a history of child abuse and differential anti-depressant response in adults suffering from major depression.2�C8) Findings have been mixed. In the largest study to date6) 808 patients suffering chronic major depressive disorder (MDD) with clinically significant child abuse (assayed with a trauma questionnaire) had lower response rates to antidepressants. Nemeroff et al.3) studied 681 patients with chronic MDD, with a trauma scale and number of abuse events used to help grade abuse severity. They found that subjects with a history of significant child abuse had preferential response to psychotherapy over the antidepressant nefazodone, with combined treatment not superior to psychotherapy alone.