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The Bayley-III test results were expressed as cognitive, language, motor developmental indexes, with a mean of 100 and a standard deviation (SD) of 15. Composite scores (cognitive, language, and motor) between 70 and 84 (?2 to ?1 SD) are considered abnormal and composite scores of less than 69 (Obeticholic Acid for children younger than the chronological age of our subjects (1, 5, and 9 months instead of 3, 12, and 24 months). Summary statistics were given as the mean?��?SD. Descriptive analyses were conducted to examine the distributions of outcome measures. Based on the modest sample size and the fact that the outcome measures were not normally distributed, groupwise comparison was performed using the Mann�CWhitney U two-sample test to compare the two groups. Statistical analysis was performed using SAS, version 9.1 (Cary, NC). As seen in Table I, cases with DS?+?AVSD were tested at approximately the same age as controls with DS???CHD, 14.5?��?7.3 months compared with 14.1?��?8.4 months (P?=?0.90), respectively. The ethnic/racial compositions were similar in both groups, and the parents of cases were slightly older than controls (P?=?0.34 for maternal age and P?=?0.36 for paternal age). Parental educational levels were similar; Doxorubicin ic50 58% of fathers in both groups and 66% (cases) and 70% (controls) FARP1 of mothers had college degrees or higher. In terms of family income, 94% of controls reported family income above $50,000 compared to 70% of cases (P?=?0.13). The composite scores in all domains for the DS?+?AVSD cases compared to the DS???CHD controls is described in Figure 1. Although the motor domain was the only domain that showed a statistically significant difference between groups (P?