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09). The recanalization time was significantly shorter in the EMT group than in the IAF group (median [interquartile ranges], 48.5 [25.3 to 87.8] minutes vs. 92 [44 to 179] minutes, P=0.01). The rate of complete recanalization was significantly higher in the EMT group than in the IAF group (87.9% vs. 41.7%, PCasein kinase 2 3. Predictors for complete recanalization with modified TICI 2b or 3 and good outcome at 3 months after stroke onset Seventeen patients with mRS��2 at 3 months Trichostatin A cell line were categorized as the good outcome group in dichotomized analysis. A statistical trend that EMT group had more chance to achieve the good outcome at 3 months than IAF group was evident (39.4% vs. 12.5%, P=0.06; Figure 2 and Table 2). In a logistic regression analysis, old age, high baseline NIHSS and baseline low pc-ASPECT score were significantly associated with functional dependency at 3 months after stroke onset. When adjusting for relevant covariates, there was no factor that was significantly associated with good outcome at 3 months (Table 3). Symptomatic intracranial hemorrhage and all-cause mortality at 3 months showed no statistical differences between the groups. Procedural complications occurred in 3 cases (12.5%) of the IAF and in 7 (21.2%) of the EMT, but it was not serious. Figure selleck inhibitor 2. Modified Rankin Scale Score at 3 months. IAF, intra-arterial fibrinolysis; EMT, endovascular mechanical thrombectomy. Low baseline pc-ASPECT score based on the DWI was significantly associated with functional dependency at 3 months in a univariate model. The optimal cutoff DWI pc-ASPECTS to predict patients with favorable outcome at 3 months, regardless the presence of complete recanalization, was ��7, with a sensitivity of 84%, specificity of 58%, and an area under the curve of 0.784 (Figure 3A). Overall, 12 (42.8%) of 28 patients with baseline ASPECT��7 and 4 (16%) of 25 patients with baseline ASPECT