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2. Vagus nerve stimulation decreased heart rate and LVP, and this was associated with a large increase in systolic and diastolic F380, hence a decrease in the diastolic and systolic level of the calcium transient (ratio). All parameters returned to baseline levels on cessation of stimulation. When left and right vagus nerves were stimulated separately, differences between the effects of the two nerves were evident. IOX1 cell line Left (LVS) and right vagus stimulation (RVS) caused a significant frequency-dependent decrease in heart rate and LVP (Table 2). There was a trend for RVS to decrease heart rate and LVP to a greater degree than LVS but this failed to reach significance. Accompanying these effects, there was a frequency-dependent decrease in the diastolic and systolic level of the calcium transient (Fig. 2B and C). There was a greater decrease in the diastolic level of the calcium transient during stimulation of both vagus nerves that resulted in an increase in the overall amplitude of the calcium transient as heart rate and LVP were decreased. The percentage decrease in the levels of the calcium transient (Fig. 2D and E) were greater during RVS than during LVS, where the effect of high-frequency RVS on the percentage decrease in the systolic level of the calcium transient (F340/F380 ratio) was significantly greater to that during high-frequency LVS. Sympathetic nerve stimulation An illustration of the effect of high-frequency (10 Hz) sympathetic nerve I-BET-762 stimulation on heart rate, LVP and Ca2+-dependent fluorescence is shown in Fig. 3. During SS there was an increase in heart rate, LVP, F340 and the calcium transient, with only minor changes in F380. All values returned to baseline after nerve stimulation was stopped. Heart rate was significantly (n= 5, P diglyceride medium- and high-frequency SS, respectively. The diastolic and systolic levels of the calcium transient were both significantly increased (P