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We speculate that actigraphic estimates of BEE may be useful for physiologically monitoring patient benefits from CPAP in OSA. ADAMS R1, APPLETON S1, VAKULIN A2, MARTIN S3, GRANT J4, MCEVOY D2, ANTIC N2, CATCHESIDE P2, TAYLOR A4, WITTERT G3 1The Health Observatory, Casein kinase 2 Discipline of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, South Australia, 2Adelaide Institute of Sleep Health, Repatriation General Hospital, Daw Park, South Australia, 3Freemason's Centre for Men's Health, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, 4Population Research & Outcomes Study Unit, Discipline of Medicine, University of Adelaide, Adelaide, South Australia Introduction:?Clinic studies report an association of untreated OSA and diabetes. However, a recent systematic GDC-0199 clinical trial review found little evidence of a longitudinal association. Aim:?To examine the relationship between previously undiagnosed OSA with diabetes and pre-diabetes in community-dwelling men aged ��40 years. Methods:?The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study is a longitudinal population-based cohort assessing diabetes status over time. At cohort follow-up only (2011�C12), n?=?837 underwent full in-home unattended polysomnography (PSG, Embletta X100). Clinic assessments at both stages included anthropometry, fasting plasma glucose (FPG), glycated haemoglobin (HbA1c) and self-reported chronic conditions (including diabetes) and risk factors. Diabetes was defined as self-reported physician diagnosis/ FPG?��?7.0?mmol/L/ HbA1c?��?6.5%/ diabetes medication use, and pre-diabetes was FPG 6.1�C6.9 or HbA1c 5.7�C6.4 (in those without diabetes). Cross-sectional analyses examined relationships between PSG indices and prevalent and incident diabetes/pre-diabetes cases. To determine longitudinal relationships in the absence of baseline PSG data, we identified probable longstanding OSA, defined as apneoa hypopnea index (AHI) ��10/h at follow-up who also had OSA symptoms at baseline (2006�C7) and stable weight over follow-up. Results:?In cross-sectional analyses, significant age adjusted odds ratios (95% CI) for prevalent diabetes [2.42 (1.41�C4.17)] Raf inhibitor review or incident diabetes [2.15 (1.04�C4.43)] associated with severe OSA (AHI?��?30) did not persist after additional adjustment for obesity. Longitudinal analyses showed that longstanding OSA was not significantly associated with incident diabetes [age-adjusted OR: 1.55 (0.74�C3.23)] but was significantly associated with incident pre-diabetes [1.83 (1.00�C3.35), p?=?0.049] after adjustment for age, obesity, smoking, physical activity, sleepiness and grip strength. There were no significant relationships of oxygen desaturation index (3%) ��16 or time oxygen saturation