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8%), but also, quite frequent hospitalization for significant heart failure worsening (12.4%). It was a result of early successful infarct-related artery opening combined with optimal pharmacological therapy, especially with beta-blocking agents. Control angiography and further CAPNS1 revascularization of the other lesions in patients with multivessel disease could also influence the outcome. Our findings suggest that MTWA test is a powerful predictor for combined endpoint including not only mortality but also worsening of heart failure and defines high-risk subgroup. Combinations of non-invasive stratifiers, increasing positive predictive value, are commonly used in clinical settings. Ikeda et al. [ 6] proposed combinations of MTWA, LVEF, non-sustained ventricular tachycardia from Holter monitoring and late potentials to increase positive predictive values for sudden cardiac death after MI. Selleckchem Talazoparib In 2007, results of the REFINE study proved that combined assessment of heart rate turbulence, MTWA and LVEFSelleckchem Dolutegravir about 20 days after index infarction, in contrary to 8 days post MI in Tapanainen patients in whom MTWA did not show to affect survival [ 15]. It could be speculated that the optimal time for MTWA assessment is later than at discharge to allow the healing process to complete and substrate to stabilize. Also, the pharmacological treatment could be better titrated after a few weeks. We have chosen day 30 for the test, however, the others have proposed to assess MTWA even later, i.e. at 6�C14 weeks. The REFINE study directly compared the assessment at 2�C4 weeks and 10�C14 weeks, proving the value of later testing [ 16]. This is the single center experience thus including small population, but rather homogeneous, consecutive at entry and constructed prospectively. There was high incidence of multivessel coronary artery disease (mainly 2-vessel and no coronary artery bypass surgery indication at entry). Therefore the patients underwent further revascularisation at 6 months, so it could influence outcomes.