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Each 2-wk treatment period was followed by a 2-wk washout period. Knemometry was performed at the beginning and end of each treatment period. Cortisol levels in 12-h overnight urine were measured at the end of each treatment period. No statistically significant differences were seen in lower-leg growth rates between CIC (0.30?mm/wk) and placebo (0.43?mm/wk) treatments. Lower-leg growth rate during FP treatment (0.08?mm/wk) was significantly reduced compared with both placebo [least squares (LS) mean: ?0.35 (95% CI: ?0.53, ?0.18; p?=?0.0002)] and CIC [LS mean: ?0.23 (95% CI: ?0.05, ?0.40; p?=?0.0137)]. Cortisol levels in 12-h overnight urine were significantly lower in the FP group when compared with CIC (p?Tofacitinib however, there were S1PR1 no statistically significant differences between each of the active treatments and placebo. CIC had no significant effect on lower-leg growth rate in children aged 6�C12?yr with mild asthma. In contrast, a similar dose of FP significantly reduced lower-leg growth rate compared with placebo and CIC. ""To cite this article: Maghni K, Malo J-L, L��Archev��que J, Castellanos L, Gautrin D. Matrix metalloproteinases, IL-8 and glutathione in the prognosis of workers exposed to chlorine. Allergy 2010; 65: 722�C730. Background:? Workers exposed to chlorine may be at risk of deterioration in FEV1. Methods:? A prospective study of 72 workers examined over a 5.8?��?1.9?year period. A sample of induced sputum for cells and mediators was obtained in 69 subjects at baseline (Vb) and in 36 both at Vb and at follow-up (Vf). Results:? Sixty-four workers (89%) experienced at least one accidental inhalation of chlorine in the interval. The mean decrease in FEV1 was 30?ml/year and thus was within normal limits. Among the analysed remodelling markers, the level of the MMP-9-TIMP-1 complex, but not of free MMP-9 and TIMP-1, significantly diminished from Vb to selleck screening library Vf. We found significant correlations between neutrophils, IL-8, MMP-9 and MMP9-TIMP-1 complex at Vb and Vf. While levels of total glutathione, IL-8, MMP9, TIMP-1 and MMP9-TIMP-1 complex were highly correlated with each other at Vb, this was inconstant at Vf. Levels of MMP9-TIMP1 complex and of TIMP1 at Vf were significantly lower in workers reporting chlorine puffs with mild acute respiratory symptoms between visits compared to those who had no, or asymptomatic inhalations (P?=?0.03 and 0.02, respectively). The fall in FEV1 from Vb to Vf was significantly correlated with levels of glutathione at Vb. Cough between visits was associated with a decrease in FEV1 (P?=?0.06). Conclusion:? Although no accelerated loss in FEV1 was documented in these workers exposed to chlorine, subjects with a greater fall in FEV1 were more likely to report cough and have higher levels of total glutathione at Vb.