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At the same time, it provides the high precision of isotope correlations. Two separation methods are usually applied in LC-MC-ICP-MS, that is, ion-exchange columns or reversed phase [26]. 3. Why Is Arsenic, Antimony, Chromium, and Thallium Epigenetics inhibitor Speciation so Important? Arsenic, antimony, chromium, and the underestimated thallium attract most interest of toxicologists and analysts. Their properties depend on the oxidation state in which they occur. Antimony is common in the natural environment and comes both from natural processes and human activity. Over the years, the human activity brought about the significant increase in its concentration in the environment due to its applications in the car industry (i.a., as an additive in the car tyre vulcanization process). The geochemical behaviour of antimony is similar to that of arsenic and bismuth [6, 27, 28]. Its biological role is not fully recognized, but it is toxic at a low level (similarly to arsenic). Sb(III) is approximately 10 times more toxic than Sb(V). That is why there is such an interest in its speciation analysis [8, 9, 28]. Antimony and its salts mainly affect the central nervous system (CNS) and blood in the toxic way. They E-64 also cause conjunctivitis and skin inflammation and damage the heart muscle and liver. The antimony compounds demonstrate mutagenic and carcinogenic effects [27, 29]. Arsenic is a toxic metalloid that is common in various biological systems and the environment. The number of its speciation forms in the environment is still increasing due to the economic growth. As the industrial pollution has not been reduced in the recent decades, the arsenic emission from the industry, steelworks, animal waste, and the dust from fuel fossil combustion is currently rising. As arsenic is very mobile, it occurs in all the environment elements. The toxicity of arsenic itself and its compounds differs. However, its inorganic chemical species are R428 about 100 times more toxic than the organic ones. The contact with arsenic can cause various health effects, such as dermatologic, inhalation, cardiologic, genetic, genotoxic, or mutagenic lesions [11]. It accumulates in the keratin-rich tissues, such as hair, skin, or nails. Arsenic and its inorganic forms can provoke cancers of the respiratory system or skin. They can also cause multiple organ cancer lesions. The dominant arsenic effects in humans are skin and mucous membrane lesions and nerve damage. Drinking water is one of the most important sources of the exposure to arsenic. The most frequent poisonings are those caused by arsenic and its compounds. It has been used for approximately 1,000 years as the rodenticide because it is colourless and has neither taste nor smell. The toxic dose of arsenic is approximately 10�C50?mg.