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These are by far the strongest candidates for further analysis in mice. Later, the Drosophila researcher mentions new exciting hits from his own functional screen, but of course he does not know whether any of these genes are even expressed in mammalian skin. The dermatologist immediately Resiquimod notices several genes on the fly researcher's list that were also strongly upregulated in her own microarrays. Together, they generate a list of genes that are required for fly wound healing and are upregulated during mouse wound healing. The high bar for investing time and money to analyse conserved but relatively unstudied genes has now been lowered substantially by this collaboration. In their review, Paricio and colleagues give dermatologists the vocabulary they need to understand some of the great tools fly researchers now have ready to offer the field. If we can cooperate to share all of the powerful features of the fly and mammalian model systems, it seems likely that the wound-healing field can truly take flight and advance towards the long-held field-wide goal of identifying all wound-healing genes. M.J.G. and A.E.A. wrote the manuscript. M.J.G. and A.E.A. created the figure, part of which was modified from work by Christine Lesch. The authors wish to thank Seol Hee Im and Heather Turner for useful comments on the manuscript. The authors declare no conflicts of interest. ""Background.? Numerous studies involving systemic lupus erythematosus (SLE) have attempted to identify gender differences in patients with lupus erythematosus (LE). However, few reports Compound Library on cutaneous lupus erythematous (CLE) have identified gender differences. Aim.? To analyse and compare the prevalence and characteristics 3-MA supplier of the main clinical and immunological features of male and female patients with CLE. Methods.? The medical records of 103 (33.4%) male and 205 (66.6%) female patients with CLE who were treated as inpatients or outpatients between January 1985 and December 2000 were retrospectively studied. All patients were reviewed in detail stratified by a predefined protocol. Results.? Female patients had a higher prevalence of Raynaud��s phenomenon (P?