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Preventive strategies did not ameliorate during the two surveyed periods, in line with other reports [5,25]. Vaccine uptake was pretty much the same with only one patient vaccinated in 2010�C2011 among ICU admitted patients; this was a bi-pulmonary transplant recipient who ultimately died. Even though inferior to that predicted by mathematical models, paying a mortality toll for a preventable disease remains a big challenge for 21st century medicine [26]. None of the pregnant women was vaccinated either; moreover they had Selleckchem BI-2536 a remarkably long course before seeking antiviral treatment (>5?days). The strengths of our study could be summarized as follows: it originates from a single centre, with a homogeneous treatment strategy, representative of a big population BML-190 base in Catalonia, Spain. The number of patients presented herein is one of the largest in the literature deriving from single centres and the analysis of the paediatric cases adds significant epidemiological data. The study has certain weaknesses. First, the small number of patients does not permit the evaluation of outcomes with significant statistical power. Second, the inclusion of a single centre does not allow for extrapolations to a more extended population. In conclusion, during the first postpandemic year, primary viral pneumonia still predominated among ICU admissions for influenza, whereas cases of sever acute respiratory infection without chest X-ray opacities increased. Enhanced vaccination practices among risk groups are warranted to prevent ICU admission and death. Early access to antiviral treatment should be strongly encouraged. The authors have nothing to selleck chemicals declare relating to this manuscript. ""At 30?years into the HIV infection epidemic, the optimal antiretroviral (ARV) regimen for infected patients with cancer remains unknown. We therefore sought to retrospectively study different ARV regimens used in this population. Data from HIV-infected patients seen at The University of Texas MD Anderson Cancer Center in Houston, Texas, USA, from 2001 to 2012 were reviewed. Patients received nucleoside reverse transcriptase inhibitors (NRTIs) plus protease inhibitors (PIs), non-NRTIs (NNRTIs), integrase strand-transfer inhibitors (INSTIs), or combinations of these. A total of 154 patients were studied. Most patients were male (80%), white (51%) and had haematological malignancies (HMs) (58%). NRTIs were combined with PIs (37%), NNRTIs (32%), INSTIs (19%) or combinations of these (11%). INSTIs were the most commonly used in patients with HM and in those receiving high-dose steroids or topoisomerase inhibitors (p