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Second, the analysis did not include dulaglutide, another QW GLP-1 RA, because it was not available at the time of this analysis. Conclusion In conclusion, this indirect comparison demonstrates the noninferiority of albiglutide to exenatide 2.0 mg QW with respect to HbA1c lowering. This finding, in the absence of head-to-head data, can be used in pharmacoeconomic analysis CB-839 in vitro and to inform health technology assessment and clinical decision making. Acknowledgments This study was funded by GlaxoSmithKline. Editorial support was provided by Joelle Suchy, PhD, and William Ho, PhD, MediTech Media, and funded by GlaxoSmithKline. Medical and clinical advice was provided by Dr Veronica Bainbridge, an employee of GlaxoSmithKline. Footnotes Disclosure Daniel Parks and Alan Martin are employees of Glaxo-SmithKline. The authors report no other conflicts of interest in this work.""Diabetes is a global public health problem that may be turning into a pandemic chronic disease. By 2030, three-quarters of the world��s 300 million adults with diabetes would live in nonindustrialized countries; almost one-third of these would live in India Succimer and in the People��s Republic of China. In 2014, the International Diabetes Federation estimated that 65.1 million Indians were living with different types of diabetes,1 predicting that this would rise up to 79.4 million by 2030.1,2 The incidence of type 1 diabetes continues to increase worldwide, and it has serious short- and long-term implications. Type 1 diabetes is one of the most common pediatric endocrine illnesses. Young patients living with type 1 diabetes �C where the pancreatic beta cells that produce insulin are destroyed because of autoimmunity �C require regular insulin therapy to survive.3,4 The incidence of type 1 diabetes in young patients is increasing at a rate of 3% per year. In 2006, the International Diabetes Federation estimated that in India selleckchem there were ?5 million young children,