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Antibiotic susceptibility to penicillin G, amoxicillin, erythromycin, clindamycin, tetracycline, gentamicin, levofloxacin and vancomycin was determined by the disk diffusion method on Mueller�CHinton agar with 5% sheep blood according to CASFM guidelines (http://www.sfm.asso.fr). Macrolides selleck kinase inhibitor and tetracycline-resistant genes were detected by multiplex PCR as described [19]. The chi-square test for trend was used and p?buy EPZ5676 age of the patients. Among those between 40 and 79?years old, cases were more frequent in men than in women (p?MAPK focal symptoms accounted for 391 (25.4%) of the cases. Gynaeco-obstetrical sepsis represented 53.2% of cases in women of childbearing age (18�C39?years, n?=?218). An STSS was described in 22% (n?=?340) of cases. It was, respectively, 3- and 1.9-fold more frequently observed in cases of NF and pleuro-pulmonary infections (p?