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Effects of polymorphisms in PCDH1 on asthma, BHR, and related phenotypes were studied comprehensively. Methods:? Genotype information was acquired from Illumina HumanHap300Chip genotyping, MALDI-TOF MS genotyping, and imputation. LD was assessed by Haploview 4.2 software. Associations Histone?demethylase inhibitor were investigated in a population of 1454 individuals (763 asthmatics) from two German study populations [MAGICS and International Study of Asthma and Allergies in Childhood phase II (ISAAC II)] using logistic regression to model additive effects. Results:? No relevant LD between PCDH1 tagging polymorphisms and 98 single nucleotide polymorphisms within the cytokine cluster was detected. While BHR was not associated with PCDH1 polymorphisms, significant associations with subphenotypes of asthma were observed. Conclusion:? Protocadherin-1 polymorphisms may specifically affect the development of non-atopic asthma in children. Functional studies are needed to further investigate the role of PCDH1 in BHR and asthma development. ""Semic-Jusufagic GUCY1B3 A, Gevaert P, Bachert C, Murray C, Simpson A, Custovic A. Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children. Pediatr Allergy Immunol 2010: 21: 1052�C1058. ? 2010 John Wiley & Sons A/S Interleukin-5 receptor ��-subunit expression may be implicated in the development of allergic diseases. In a population-based birth cohort, we investigated the relationship between IL-5R�� and the development of allergic phenotypes in childhood, using soluble IL-5R�� (s-IL-5R��) as a marker. Children (n?=?510) were followed from birth and assessed at age 3, 5 and 8. Based on the onset and resolution of symptoms, we assigned children into the following wheeze and eczema phenotypes: never, transient, persistent, intermittent and late-onset. KD-025 Specific IgE to common allergens, s-IL-5R�� (ELISA) and urinary eosinophilic protein X (U-EPX) levels was measured at age 5. s-IL-5R�� was significantly higher among atopic compared to non-atopic children (pg/ml, geometric means [95% CI], 152.4 [126.0�C184.5] vs. 103.4 [94.0�C113.9], p?