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89% and sepsis 3.1%. The differences in complication rates may be due to the particular biopsy preparation protocol or actual biopsy method. Some authors favor prophylactic antibiotic use before biopsy, while others support bowel cleansing. According to a Cochrane review, the use of enema did not decrease the risk Unoprostone of developing sepsis, it only lowered the risk of subsequent bacteremia [17]. Ruddick et al. reported that the 24�Chour clear�Cfluid diet and the use of disposable enemas, combined with a regimen of ciprofloxacin, decreased the rate of post�Cbiopsy sepsis, but the results, however, were not statistically significant [18]. Besides, according to Carey and Korman, pre�Cbiopsy enemas increase cost and patients�� discomfort without providing a clinically�Csignificant outcome advantage [19]. In the present study, we used prophylactic antibiotics and did not attempt any bowel cleansing. The patients were instructed to come to the clinic on an empty stomach in the morning. In a study investigating the association between comorbidities in patients undergoing prostate needle biopsy and biopsy�Crelated infections, Protease Inhibitor Library screening Carignan et al. reported that DM, chronic obstructive pulmonary disease and a history of hospitalization within the preceding month are independent risk factors for post�Cbiopsy infection [9]. After reviewing the medical background of our patients who developed sepsis, we noticed that 6 out of these 28 patients had DM. However, the relationship between the risk of developing sepsis and DM was not found to be statistically significant (p >0.05). this website One of our sepsis�Cpositive patients potentially had an occupational disease, as a butcher, who developed Brucella spp. sepsis. Nam et al. have found a significant relationship between the number of biopsy cores and post�Cbiopsy sepsis [10]. In our study, we detected a significant association between pre�Cbiopsy WBC count and biopsy�Crelated sepsis (p