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3%) in JAK2V617F wild-type, 10 of 40 (25%) in patients with low JAK2V617F allele burden, and 4 of 18 (22.2%) in patients with high JAK2V617F allele burden (P=0.957). The prevalence of hydroxyurea use, ASA use, rate of AHSCT, and history of splenectomy showed no difference between PMF patients with and without ASXL1 mutation. Similarly, no significant differences were find more observed in the use of other medical treatments between two groups (P>0.05). One of the ASXL1-mutated PMF patients had received oxymetholone but no cytoreductive treatment (Table 1). DIPSS-plus risk stratification did not differ between PMF patients with and without ASXL1 mutation (P=0.803). Distribution of karyotype categories was similar between two groups: 89.5% normal, 10.5% favorable, and 0% unfavorable karyotype in ASXL1-mutated PMF patients and 86.2% normal, 8.6% favorable, and 5.2% unfavorable karyotype in ASXL1 wild-type PMF patients (P=0.589). Duration of follow-up was similar between PMF patients with and without ASXL1 mutation (mean 51.5 months [SD, 48.6] and 43.6 months [SD, 47.4], respectively; P=0.382). ASXL1 mutant PMF patients showed higher rates of death compared with ASXL1 wild-type PMF patients (42.1% and 10.3%, respectively; P=0.004). The rate of leukemic transformation was higher in ASXL1-mutated PMF than in wild-type counterparts, but with no statistical significance (10.5% and 3.4%, respectively; P=0.253). In PMF patients, the presence of ASXL1 mutation did not correlate with HCT level, total leukocyte count, platelet count, LDH level, mean spleen size, total thrombotic events, arterial thrombosis, and venous thrombosis (rVenetoclax In PMF, a mild positive correlation was found between ASXL1 mutation and bleeding complications (r=0.327). Further on, we observed a mild positive correlation between bleeding events and the copresence of ASXL1 and JAK2V617F mutations, whereas no such correlations were found between the other Histone demethylase aforementioned parameters and combined ASXL1 and JAK2V617F mutations (r=0.363 and r