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0 [Graph Pad Inc., San Diego, California, USA]) was employed for group comparisons. Pearson correlation Selleckchem DAPT secretase coefficient was calculated in Excel (Microsoft Office Excel 2007). Significance for correlation was calculated with public Statistics Calculator version 3.0 (http://www.danielsoper.com/statcalc3/calc.aspx?id=44). Statistical significance was determined at p?Tolmetin mast cells and eosinophils. There was a significant positive correlation (r?=?0.34; p?=?0.0057) between eosinophil and mast cell counts in the control mucosal samples (Fig.?1a). However, in those biopsy samples from the patients with EGID where the eosinophil counts were above normal limits (n?=?26), there was no significant correlation (r?=??0.11; p?=?0.59) between eosinophils and mast cell numbers (Fig.?1b). Next, we examined the difference between control and EGID mast cells numbers according to anatomic locations (stomach, duodenum, terminal ileum, right/left colon). Only those EGID biopsies were compared, where eosinophil counts fulfilled the criteria for disease. In none of the areas, did we find a significant differences between control and EGID (stomach p?=?0.32; duodenum p?=?0.57; terminal ileum p?=?0.12; and colon p?=?0.92). EGID is histologically characterized by increased infiltration of eosinophils in the gastrointestinal tract and a wide range of common symptoms such as abdominal pain, vomiting, Selleck Proteasome inhibitor and diarrhea. As it is relatively uncommon condition, the prevalence and clinical associations of pediatric EGID are unclear [4]. However, approximately 2�C8% children manifest IgE and non-IgE food allergies. There is limited understanding of the key mediators that may play a role in the pathogenesis and symptoms of EGID. Mucosal mast cell infiltration has been described in other gastrointestinal diseases, such as celiac disease, inflammatory bowel disease, and diarrhea predominant irritable bowel syndrome [5-7] as well.