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However, it is good to see that the changes in diagnostics have started towards the end of the last century, assisted by the progress of biotechnology and the late riser's alertness to the problem. The balance between developments in the diagnosis and in the treatment of tuberculosis has changed. Recent diagnostic advances overweigh the inefficient progress of new drug development against tuberculosis selleck chemicals by far. Today, we have the technology to rapidly identify individuals with smear-positive MDR or XDR tuberculosis, but we do not have the drugs to treat these patients adequately.8,301 This article has overviewed such changing aspects of each of the established diagnostic techniques as summarized in Table?6. Every technique listed here was discussed in respective chapters focussing on its current and possible further improvement. Also, we have reviewed the ongoing efforts of innovations for novel modalities. Many of them are quite promising, so that we will be able to make it out of the antiquated techniques and make a full use of new techniques fitted to various situations. Only in that way can we combine our case-finding activities well with treatment services that Vatalanib (PTK787) 2HCl are still progressing in order to make our tuberculosis control maximally effective. The authors thank Dr Martina Sester (University of Saarland, Homburg, Germany) for stimulating discussions on the diagnosis of tuberculosis. ""6186" "Whether the therapeutic nasal continuous positive airway pressure (CPAP) derived from manual titration is the same as derived from automatic titration is controversial. The purpose of this study was to compare the therapeutic pressure derived from manual titration with automatic titration. Fifty-one patients with obstructive sleep apnoea selleck compound (OSA) (mean apnoea/hypopnoea index (AHI)?=?50.6?��?18.6 events/h) who were newly diagnosed after an overnight full polysomnography and who were willing to accept CPAP as a long-term treatment were recruited for the study. Manual titration during full polysomnography monitoring and unattended automatic titration with an automatic CPAP device (REMstar Auto) were performed. A separate cohort study of one hundred patients with OSA (AHI?=?54.3?��?18.9 events/h) was also performed by observing the efficacy of CPAP derived from manual titration. The treatment pressure derived from automatic titration (9.8?��?2.2?cmH2O) was significantly higher than that derived from manual titration (7.3?��?1.5?cmH2O; P?