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Establishment of pharmacovigilance centers with effective monitoring and reporting will play a significant role in preventing and managing the ADRs. Limitations The study included only adult and geriatric population admitted in Pulmonolgy Department Although respiratory diseases like asthma and other RTIs are common in children, pediatric population was excluded owning difference in the biological and physiological make-up of children and also that pediatric patients were admitted in altogether different hospital, which was beyond the scope of the study Further larger studies involving all age groups may be helpful in rationalizing the drug therapy in respiratory diseases. Conclusion A relatively high incidence of adverse drug events (32.2%) have been recorded which shows that not only geriatric patients Ceritinib order but also adults are more susceptible to adverse drug effects. A number of drugs in combination were used, and ADEs Pictilisib mouse often get multiplied. Careful therapeutic monitoring and dose individualization is necessary. The incidence of ADRs was highest in geriatric patients. Nonetheless, adult patients also showed higher incidence, which could attribute to the use of multiple drugs administered, to minimize this high incidence of ADRs dose individualization and therapeutic monitoring of drugs is essential. Clinical studies to elicit the toxicodynamics of these ADEs and safety versus risk issues could be beneficial in devising strategies for its rational use in respiratory diseases. Acknowledgment We express our thanks to Dr. S.A AzeezBasha, Principal, Deccan School of Pharmacy for necessary facilities, helping and motivating us during the project work. We also thank Dr. Aleem (Pulmonologist, Esra Hospital) for providing valuable guidance and continuous encouragement. Footnotes Source of Support: Nil Conflict of Interest: None declared.""A 50-year-old white man presented to the emergency department with malaise, weakness, abdominal pain, and loss of vision that progressively ARAF worsened over 3 days. He has a history of a long-standing well-controlled type 2 DM treated with insulin, glyburide, and metformin. 4 days before admission his endocrinologist stopped his Lantus (insulin glargine) and prescribed him on canagliflozin 100 mg oral daily along with glyburide and metformin. After 10 days of treatment, he developed malaise, weakness, abdominal pain that progressively worsened. On the day of the presentation, he developed blurry vision. Physical examination in the emergency department was remarkable for dry lip and epigastric tenderness. Blood test showed blood glucose of 506 mg/dL; sodium of 125, potassium 6.8, chloride of 94, total carbon dioxide