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The use of resources and their associated costs were compared as recommended by Thompson and Barber using a general linear model (analysis of covariance [ANCOVA]) adjusted for the covariates sex, age, overall comorbidity (RUB, Charlson index), illness duration, the MPR, and treatment persistence.30 Pairwise comparisons were adjusted to the procedure to estimate marginal means using the Bonferroni correction to estimate the P-value of statistical significance. Data were presented as adjusted mean differences between treatments with their respective 95% confidence interval calculated with re-sampling techniques (bootstrapping) corrected for bias, given the non-normal distributions of Selleckchem Epigenetics Compound Library the resource utilization and cost variables. Pain intensity and severity of anxiety symptoms were analyzed after performing a single imputation of missing values using a general linear model (ANCOVA) for absolute and relative variation between start and discontinuation of treatment of the pain and anxiety scores, respectively, and using a logistic regression model for the proportion of patients who were responders or in remission in terms of anxiety symptoms (score Evodiamine pain/mild pain (score BMS-777607 chemical structure Missing values in the NRS were observed in 9.7% of patients receiving gabapentin, with no significant difference between brand (8.5%) and generic (10.2%), P=0.382. On the HAM-A scale, missing values were observed in 22.2% of patients receiving venlafaxine, also with no significant difference between brand (20.3%) and generic (23.8%), P=0.258. Imputation method was WOCF (worst available observation carried forward), which in this case was the score observed at the start-of-treatment visit. For both scales, we compared the scores at the first and final visits, absolute (points) and relative (%) variation of pain intensity and anxiety severity between visits, proportion of responders (reduction ��50% from the initial score in pain intensity or anxiety severity at the final visit) and proportion of patients in remission in terms of anxiety symptoms (HAM-A