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As shown in Table?2, resistence rates to vancomycin, ciprofloxacin, nitrofurantoin, gentamicin, and oxacillin were zero, followed by tetracycline and amoxicillin with clavulanic acid (6.2%) and cephalosporins (14.3%), whereas cultures were completely resistant to penicillin and ampicillin. Based on the severity of the impaired skin and clinical judgment, and excluding drugs contraindicated in newborns, selected antibiotics were administered (Table?3). Statistical comparison of the length of hospitalization was performed according to antibiotic therapy (Table?3). There were no significant differences in response to therapy between ��-lactamase-resistant semisynthetic penicillin (��RSP was one kind of amoxicillin with clavulanic acid), cephalosporins, or both, although patients treated with ��RSP and cephalosporins Regorafenib solubility dmso Floctafenine together plus intravenous gamma globulin (4 cases) had significantly longer hospitalizations than those (24 cases) who were not (p?Torin 1 ranged from 1 to 22?days (median 9.0?days). S.?aureus causes a variety of infectious diseases, ranging from superficial skin infections to severe, toxin-mediated systemic infections. SSSS is a type of systemic disorder mainly caused by coagulase-positive group II S.?aureus (especially strain 71) that can cause superficial skin blistering. Skin acantholysis leads to cracks in the epidermis and characteristic skin bullae [8]. Admissions to our hospital indicated a significant upward trend of SSSS incidence in the last 8?years, similar to other published reports [9, 10]. The average incidence was more than twice as great as in developed countries such as the Czech Republic [4]. The number of affected boys was much greater than the number of girls (ratio ~9:5), which is consistent with the results of another large-sample series [4].