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The subjects with both risk alleles showed a trend towards reduction in gray matter volume in superior frontal, medial frontal, lingual, inferior parietal and anterior cingulate gyri in the right hemisphere and bilateral cerebellum at p selleck chemical volumes linked to the additive effect of the three risk alleles S (5HTTLPR), G (rs4680) and T (rs6314) (subjects with 2 or 3 risk alleles [n=53] vs. those with 1 or no risk alleles [n=27]), irrespective ... Table 9 Brain regions showing reduced gray matter volumes linked to the additive effect of the three risk alleles S (5HTTLPR), G (rs4680) and T (rs6314) irrespective of phenotype DISCUSSION We examined the influence of polymorphisms of three schizophrenia candidate Isotretinoin genes mediating monoamine signalling on regional brain volumes. We found greater regional brain volumes in left inferior temporal and left inferior occipital gyri in carriers of the T allele of rs6314 polymorphism of 5HT2A gene at a statistical significance threshold of FWEc pmTOR inhibitor volumetric reductions in schizophrenia.3,54,55) However the reported volumetric abnormalities vary from study to study, perhaps due to the effect of various confounding factors apart from differences in the constitution of genotypic risk variants,56) such as age, gender distribution, age of onset, duration of illness, exposure to neuroleptics and drug use across the samples studied.4�C8) The absence of volumetric reductions in our sample of patients with schizophrenia at a stringent significance threshold (FWE p